P-P29 The glycated haemoglobin (HbA1c) test is not a predictor of pancreatectomy specific complications or survival

نویسندگان

چکیده

Abstract Background The glycated haemoglobin (HbA1c) test is a venous blood used as diagnostic for diabetes mellitus and to monitor glucose control in patients known have diabetes. has been recommended by National Institute Health Care Excellence (NICE) clinical guidelines the pre-operative setting since 2016. purpose of testing reduce perioperative morbidity mortality optimising management levels period. aim this study was assess prognostic value HbA1c pancreatic cancer treated with pancreaticoduodenectomy. Methods This retrospective analysis prospectively managed database resections at single institution from January 2016 December 2020. Included had confirmed adenocarcinoma underwent pancreaticoduodenectomy preoperative measurement their HbA1c. Patients who were already prescribed insulin excluded. Demographic data, survival, operative details collected. patient records assessed incidence postoperative complications accordance International Study Group Pancreatic Surgery fistula, delayed gastric emptying post pancreatectomy haemorrhage. An greater than 41 deemed elevated. Results There 145 met inclusion criteria. level normal 101/145 (70%) elevated 44/45 (30%). fistula rate 18% 23% those (p = 0.499). 21 respectively. five relaparotomies overall, one these an no deaths. Overall survival 31months (95%CI 27-35) HbAlc 32months 27-38) if Conclusions little doubt that helpful package assessment tests optimise surgery. However, planned not predictive specific such emptying, relaparotomy or mortality. In addition, long-term overall influenced HbAlc.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Glycated Haemoglobin: A Predictor of Vascular Risk?

Glycated haemoglobin (HbA1c), a marker of average glycaemia during the previous six to eight weeks, is a predictor of microvascular complications in diabetic individuals. However, the role of HbA1c as a predictor of macrovascular complications (e.g. myocardial infarction or stroke) in these patients is not clearly defined. In contrast, new evidence suggests that HbA1c can predict the risk of ca...

متن کامل

Glycated haemoglobin--a marker and predictor of cardiovascular disease.

Glycated haemoglobin is formed by simple chemical reaction between haemoglobin and blood glucose. It represents a reliable and moving average of blood glucose over preceding three months. In 2009 the International Expert Committee recommended the use of HbA1c to diagnose diabetes with a cut-off of 6.5%. Studies have shown that HbA1c even in the range of 5.5% to 6.5% poses considerably high risk...

متن کامل

Labile glycated haemoglobin and carbamylated haemoglobin are still critical points for HbA1c measurement

INTRODUCTION Haemoglobin A1c (HbA1c) is a key analyte for the monitoring of glycemic balance in diabetic patients and is used for diabetes diagnosis in many countries. The potential interference of carbamylated haemoglobin (cHb) and labile glycated haemoglobin (LA1c) on HbA1c assays must remain a matter of vigilance. Such a situation has occurred in our laboratory with a kit replacement on the ...

متن کامل

The True Value of HbA1c as a Predictor of Diabetic Complications: Simulations of HbA1c Variables

AIM The updated mean HbA1c has been used in risk estimates of diabetic complications, but it does not take into account the temporal relationship between HbA1c and diabetic complications. We studied whether the updated mean HbA1c underestimated the risk of diabetic complications. METHOD Continuous HbA1c curves for 10,000 hypothetical diabetes patients were simulated over an average of 7 years...

متن کامل

Guidance concerning the use of glycated haemoglobin (HbA1c) for the diagnosis of diabetes mellitus.

Glycated haemoglobin (HbA1c) assessment for the diagnosis of diabetes mellitus overcomes many practical problems associated with traditional blood glucose measurements. However, the test is not without limitations of which the medical practitioner needs to be aware. The possibility of an individual having a medical condition that interferes with the test should always be considered, even though...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: British Journal of Surgery

سال: 2021

ISSN: ['1365-2168', '0007-1323']

DOI: https://doi.org/10.1093/bjs/znab430.252